In addition, studies into the SNPs C282Y (rs1800562) in the hereditary hemochromatosis gene (HFE) and A736V (rs855791) in the transmembrane serine protease 6 gene (TMPRSS6), which have repeatedly been associated with the iron parameters, only associated with the ratios hepcidin/ferritin and hepcidin/TS and not with serum hepcidin [25]. This evidence concerns the gene HAMP and hereditary hemochromatosis.