RHO and colorectal cancer: Based on the statistically significant definition with FDR p-values<0.05, the annotated most enriched pathways were found to be tightly linked to “dorso-ventral axis formation (GRK-EGFR)” (which modulates the key effectors in axis formation such as Rho and Notch) and “colorectal cancer” (which is involved in the carcinogenic signaling transductions of genomic alternations resulted from chromosomal and microsatellite instabilities) (Table 6).