EP300 and neoplasm: In both A549 and PC-3 tumour sections, increases in pro-apoptotic and cell cycle regulator protein levels were observed in p21, cleaved caspase-3 and p300, while angiogenic biomarker vascular endothelial growth factor (VEGF) and inflammatory biomarkers histone deacetylase 2 (HDAC2), cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) were significantly reduced compared to placebo levels (Figure 6).