And requiring that future studies of Gal-3-Na+/K+-ATPase biology would include Gal-3/Na+/K+-ATPase/Src axis consideration as it may provide new insight to understand the pathophysiology of multiple Gal-3-overexpressing diseases such as immune diseases, metabolic diseases and fibrosis as well as cancer. The gene discussed is LGALS3; the disease is metabolic disease.