Furthermore, a mouse model developed by Gerbaulet et al. [60] that shows many cardinal features of human mastocytosis due to the presence of the activating KIT D814V mutation and can be induced to express in multiple hematopoietic stem and progenitor cell lineages (stem cells vs. mast cells), can be further utilized to determine the role of various signaling molecules described above by targeting them using pharmacological inhibitors or genetic ablation, and analyzing their contribution to the development of mastocytosis. The gene discussed is KIT; the disease is mastocytosis.