CREB1 and mastocytosis: Active AKT is readily detected in neoplastic MCs obtained from mastocytosis patients, and in human mastocytosis patient derived cell line HMC1.2 active AKT regulates downstream targets like FOXO, NF-kB, and CREB, resulting in anti-apoptotic and sustained cell survival signals that can contribute to malignant growth of neoplastic MCs [32, 66, 67].