DNMT3A and systemic mastocytosis: A few studies reported a slightly lower rate of mutations in genes such as CBL (3.8%-20.5%), DNMT3A (12%), KRAS, NRAS, JAK2, EZH2 (5.1%) and ETV6. CBL mutations were mostly found in patients with SM-AHNMD, while DNMT3A and EZH2 mutations were primarily seen in SM patients [43, 53, 54, 56, 59].