Binda et al.7 showed that EphA2 drives self-renewal and tumorigenicity in cancer stem cells derived from human glioblastoma, in which a strong signal for pS-EphA2 was detected in stem-like tumour propagating cells, but not in differentiated astrocytoma and neuroblastoma, in an ephrin-A ligand-independent manner. The gene discussed is EPHA2; the disease is neuroblastoma.