Consistent with other studies, we have observed strong cross-sectional associations between copeptin and eGFR, liver enzymes, insulin resistance, and a cluster of cardiometabolic risk factors including hypertension, abdominal obesity, and the dyslipidemia characteristic of insulin resistance (high triglycerides and low HDL-C) (9, –, 13). The gene discussed is AVP; the disease is metabolic syndrome.