To this end, the human OCT4 pseudogene OCT4-pg4 was demonstrated to sponge OCT4-specific miRNAs in hepatocellular carcinoma cells45; human OCT4-pg5 anti-sense transcripts reduce OCT4 promoter activity and mouse OCT4-pg1 impacts on mesenchymal stem cell differentiation via a still unknown mechanism39, 46. This evidence concerns the gene POU5F1 and hepatocellular carcinoma.