Mutations in NALP3 are associated with hereditary autoinflammatory conditions, including Muckle–Wells syndrome and familial cold autoinflammatory syndrome.30, 31 Using BiFC to measure caspase-1 dimerization has allowed us to identify the conditions under which caspase-1 is recruited to different inflammasomes. The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.