Recently, the co-chaperone Bcl-2-associated athanogene 3 (BAG3) that modulates age-related autophagic activity was shown to diminish proteotoxicity via selective autophagy and is highly expressed in estrogen receptor-positive neuroblastoma and breast cancer cells.17, 18, 19, 20, 21. The gene discussed is ESR1; the disease is breast cancer.