Recently, the co-chaperone Bcl-2-associated athanogene 3 (BAG3) that modulates age-related autophagic activity was shown to diminish proteotoxicity via selective autophagy and is highly expressed in estrogen receptor-positive neuroblastoma and breast cancer cells.17, 18, 19, 20, 21. This evidence concerns the gene ESR1 and neuroblastoma.