For instance, upregulated miR-10b and miR-192/215 were reported to indicate chemosensitivity to 5-fluorouracil-based chemotherapy.18, 19 Additionally, miR-18a downregulation was associated with poor survival in CRC patients, and its expression predicted progression-free survival in epidermal growth factor receptor-targeted therapy.20 Overall, these results indicate a link between miRNAs and the development of CRC. This evidence concerns the gene EGFR and colorectal carcinoma.