AKT1 and cancer: AKT is an evolutionarily-conserved serine/threonine kinase involved in the PI3K/AKT signaling pathway, which regulates cellular processes such as cell proliferation, apoptosis, migration, and metabolism.29, 30 The PI3K/AKT signaling pathway is recognized as one of the most frequently activated signaling pathways in human cancers and forms a major link between oncogenic receptors and downstream prosurvival molecules.