AKT1 and malignant colon neoplasm: In contrast, AKT2 is abnormally expressed in breast, ovarian and colon cancers, and AKT3 is amplified in breast and prostate cancers.29, 30 Although AKT1 and AKT3 are generally associated with other tumor types, they are highly conserved with AKT2 and involved in tumor proliferation and metastasis.