miR-612 levels in hepatocellular carcinoma (HCC) patients were inversely associated with tumor size, stage, epithelial–mesenchymal transition (EMT), and metastasis.21 Importantly, miR-612 inhibited cell proliferation, migration, invasion, and metastasis by targeting AKT2 in HCC, suggesting its negative role in tumor development.21 However, the role of miR-612 in CRC pathogenesis remains unknown. Here, AKT2 is linked to colorectal carcinoma.