To clarify the impact of miR-612 on CRC metastasis, xenograft animal model of liver metastasis using the indicated CRC cells was therefore established, showing that the size of liver focal lesion because of colorectal tumor cell metastasis was significantly smaller by miR-612 overexpression, which was partially reversed by AKT2 overexpression (Figure 5d). Here, AKT2 is linked to colorectal neoplasm.