In germinal center B-cell-like (GC) DLBCL cells, targeting NAE resulted in accumulation of Cdt1, DNA re-replication and cell cycle arrest in S phase, reminiscent of the consequences of NAE inhibition in adherent human colorectal carcinoma HCT116 cells.15, 16 In contrast, in activated B-cell-like (ABC) DLBCL cells, abrogation of transcriptional activity of NF-κB was the dominant event that preceded apoptosis.8 The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.