PMAIP1 and B-cell chronic lymphocytic leukemia: As we have previously demonstrated that MLN4924 induces BH3-only proteins BIM and NOXA in CLL cells,4 and bendamustine induces NOXA in non-Hodgkin's lymphoma cells,25 we investigated whether the cooperative effect of these two drugs was due to enhanced upregulation of these pro-apoptotic B-cell lymphoma 2 (BCL2) family members.