In contrast, TCF21, a transcription factor involved in mesodermal development whose promoter is in a DMV, showed significant and consistent hypermethylation (average ß-value 0.78) of the promoter region in CCSKs, while the promoter region of favorable histology Wilms tumors was hypomethylated (average ß-value 0.14) (Figure 4, Figure 5A). The gene discussed is TCF21; the disease is Wilms tumor.