IRX4 and Nephroblastoma: Analysis of these data yielded the following observations: (1) hypermethylation of HOXA1 and OSR2, and hypomethylation of MCF2L was dispersed rather than localized, interspersed with probes showing a normal methylation pattern, and the differentially methylated probes were not located in regions that regulate transcription and (2) PAX2, SOX1, IRX4 and EMX2 displayed hypomethylation in both CCSKs and favorable histology Wilms tumors in regions located within or downstream of DMVs [23]; coordinated methylation patterns were not apparent by Integrative Genome Viewer (IGV).