PDK1 and neoplasm: To identify optimal therapeutic strategies, we first screened our tumor cell lines for growth inhibition and cell death after exposure to chemical inhibitors of MEK (PD0325901 and GSK1120212), PI3K (BEZ235 and GDC0941), PDK1 (OSU03012), and AKT (MK2206) at clinically achievable doses of ~ 0.1 μM.