MYC and diffuse large B-cell lymphoma: Stasik et al. [23] recently described a colorimetric in situ hybridization (CISH) method for detecting extra copies of the MYC gene in DLBCL and frequent occurrence of excess copies of discrete MYC signals (38%) in the context of diploidy or polyploidy of chromosome 8, which was correlated with increased mRNA signals and poor outcome.