Strikingly, whereas neither GC-derived B cell lines nor FL and DLBCL primary B cells secreted IL-8 (data not shown), IL-8 was significantly increased in FL-invaded BM plasma compared with normal BM plasma (202.4 pg/mL [7.5-20.000] vs 17.9 pg/mL [7.5-54.2]; Figure 2A). Here, CXCL8 is linked to diffuse large B-cell lymphoma.