LEP and obesity due to melanocortin 4 receptor deficiency: Curcumin can regulate the expression of genes involved in energy metabolism, lipid accumulation, and lipogenesis such as PPARγ, suppress angiogenesis, improve obesity-associated inflammation and obesity-induced metabolic disorders such as insulin resistance, hyperglycemia, and hyperlipidemia, protect from liver injury, prevent LDL-C oxidation, increase adiponectin production, decrease hepatic NF-κB activity and inflammatory markers of liver, reduce body weight gain, adiposity, and microvessel density in adipose tissue, and reduce leptin resistance [111].