In contrast, the NHE3 gene (encoding the NHE3 Na+/H+ exchanger functionally coupled to SLC26A3) and the evolutionarily related SLC26A9 gene (highly expressed in apical membrane of mouse stomach and duodenum, Liu et al., 2015) were detected as CF meconium ileus modifier genes (Sun et al., 2012). This evidence concerns the gene SLC26A3 and intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.