AR and Crouzon syndrome-acanthosis nigricans syndrome: Androgen receptor (AR) is one of the MF-CAN proteins associated to a disease pair showing a comorbidity pattern (Supplementary Data Sheet 2): prostate cancer (PC) and spinal and bulbar muscular atrophy (SBMA, ICD-9: 335.1), an illness leading to progressive muscle weakness and atrophy, known also as Kennedy's disease.