In the setting of ELN in human RA synovium, however, we did not observe preferential IL-23 p19 expression at the specific sites of ELN and failed to demonstrate an induction of ELN-associated chemokines such as CCL21 and CXCL13 by exposure of FLS to IL-23 and IL-17A. This evidence concerns the gene CCL21 and rheumatoid arthritis.