To understand the mechanism of SLC34A2 involved in tumorigenesis and progression of NSCLC, western blot was performed to detect the expression levels of related signalling protein, including PI3 Kinase, phospho-AKT, AKT phospho-mTOR, mTOR, phospho-MEK1/2, MEK1/2, phospho- Erk1/2, Erk1/2 and Cyclin D3 in A549 and 95D cells, which were transiently transfected with pcDNA3.1-SLC34A (P-S) or pcDNA3.1 (P) for 48 h respectively. The gene discussed is CCND3; the disease is non-small cell lung carcinoma.