Vascular endothelial growth factor (VEGF) plays a key role in intraocular neovascularisation in a number of conditions; it not only promotes angiogenesis (by stimulating vascular endothelial cell proliferation and migration) but also increases vascular permeability.5 VEGF-A, acting via the VEGF receptor 2, is thought to be the main stimulator of angiogenesis and vascular permeability in wet AMD.5 The gene discussed is VEGFA; the disease is wet macular degeneration.