APP and Alzheimer disease: Inflammatory process far from plaques was significantly worsened in APP/PS1-STZ-treated mice (F(3,1382) = 42.25, **p = 0.01 vs. the rest of the groups, ‡‡p < 0.01 vs. Wt-Sham) (Fig. 4a, c), supporting a synergistic effect between diabetes and AD at this level.