APP and Cognitive impairment: On the second retention phase (72 h after completion of the acquisition phase), we observed that memory dysfunction was statistically significant in the Wt-STZ group, and cognitive impairment was worsened in APP/PS1-STZ animals (F(3,24) = 45.13, ††p = 0.006 vs. Wt-Sham and APP/PS1-Sham, ‡‡p < 0.01 vs. Wt-Sham) (Fig. 1c).