Genetic screening is of limited value in adult patients with sporadic FSGS, with the exception of screening for the podocin p. R229Q in young adults since compound heterozygosity for p.R229Q coupled with a pathogenic NPHS2 mutation is associated with adult-onset SRNS, mostly among patients of European and South American origin. This evidence concerns the gene NPHS2 and focal segmental glomerulosclerosis.