TTR and Ataxia: In contrast, severe meningovascular amyloidosis is associated with certain TTR gene mutations, including Leu12Pro [6], Asp18Gly [7, 8], Ala25Thr [9, 10], Val30Gly [11–13], Val30Met [14, 15], Thr49Pro [16], Leu58Arg [17], Phe64Ser [18], Tyr69His [19–21] and Tyr114Cys [22], and can lead to dementia and ataxia.