DICER1 and DICER1-related tumor predisposition: This notion results mostly from the observation that the overall level of miRNAs is often reduced in cancer [60–62] and from the fact that germline loss-of-function mutations in DICER1 are causative variants in the so called DICER1 syndrome, which is associated with increased risk of numerous, mostly early, childhood malignancies and benign tumors [63].