To characterize the function of miR-29b, U251 and U87MG GBM cells were transiently transfected with synthetic miR-29b or miR-29b inhibitor, which revealed that miR-29b markedly hindered their migratory and invasive capacities when compared to a scrambled miRNA-transfected cells (miR-C) (Figure 2A, top) by inhibiting MMP-2 activity and protein expression (Figure 2B). The gene discussed is MMP2; the disease is glioblastoma.