Furthermore, we must not forget that this neuroprotective property of PrPC is further supported by other in vivo models, such as transient knockdown of Prnp homologs in zebrafish71, and also some in vitro experimental approaches including PrPC downregulation and detachment of the plasma membrane in neuronal primary cultures and neuroblastoma cell lines (18, 19, 20 and present results). Here, PRNP is linked to neuroblastoma.