All three patients had relatively high HIV viral load, which can be related with malaria co-infection because malaria is associated with a strong CD4 + lymphocyte activation and up-regulation of pro-inflammatory cytokines, providing an ideal microenvironment for the spread of HIV among CD4 + cells and thus for a rapid replication that clinically can be seen by the increased HIV viral loads. This evidence concerns the gene CD4 and coinfection.