Additionally, Tikellis et al. (2014) increased the plasma MG levels of mice to the levels observed in diabetic mice by addition of 1% MG to the drinking water and by inhibiting its primary clearance enzyme, glyoxalase I. Euglycemic mice with increased MG levels showed increased vascular adhesion, inflammation, and augmented atherogenesis, and the pathophysiology was similar to that observed in hyperglycemic mice with diabetes. The gene discussed is GLO1; the disease is diabetes mellitus.