In a detailed study of resected tumor tissue from 146 primary, invasive, non-metastatic breast cancers, the density of HEVs (number of vessels/tumor area) correlated with the numbers of infiltrating naive, memory and granzyme+ CD8+ T cells as well as a gene expression profile typical of Tbet, Th1, CD8+, and IFNγ+ cells.76 The gene discussed is CD8A; the disease is breast carcinoma.