In mice, tumor blood vessels are anergic to inflammatory cytokines that upregulate CD8+ T cell homing in non-involved peritumoral vessels129 and tumor-derived factors, such as endothelin-B, suppress T cell recruitment by limiting endothelial expression of homing-associated molecules such as ICAM-1 and VCAM-1.130. The gene discussed is CD8A; the disease is neoplasm.