For example, Justo et al. have investigated the relationship between genetic variability in USPL1 (ubiquitin-specific peptidase-like 1) that was identified as a SUMO isopeptidase and involved in the regulation of sumoylation and breast cancer and further drew a conclusion that functional nsSNPs in USPL1 called “rs7984952” which are implicated in amino acid exchanges from leucine to serine at position 531 was associated with risk for grade-3 breast tumors29. This evidence concerns the gene USPL1 and breast carcinoma.