However, the patient’s clinical features were typical of idiopathic PD, The use of [123I]-(1r)-2β-carboxymethoxy-3β-(4-iodophenyl)tropane ([123I]-b-CIT) that is known to bind to DAT with high affinity and low nonspecific binding [126] in single-photon emission computed tomography showed severe reduction of striatal β-CIT binding in the two patients with Mn-induced parkinsonism, which is consistent with PD. This evidence concerns the gene SLC6A3 and Parkinson disease.