Using a T2DM genetic risk score of 34 SNPs the Diabetes Prevention Programme (DPP, n = 2843), reported a trend for a lower estimated insulin secretion (insulinogenic index) for a higher genetic risk score at baseline, but no interaction between genetic risk and treatment on change in insulin sensitivity or secretion indices following 12 months of intensive lifestyle modification or metformin treatment [36]. This evidence concerns the gene INS and diabetes mellitus.