Adjuvant MNP anti-IL6 siRNA suppressed the thermal ablation-induced effects on distant R3230 tumor growth such that the mean tumor size at 7d with combination therapy was lower than either the sham (non-ablation) and hepatic RFA alone groups (p = 0.02 vs. sham, p<0.001 vs. hepatic RFA alone; Fig 3A, Table 1). Here, IL6 is linked to neoplasm.