IL6 and neoplasm: Here, we build on our earlier experience using nanoparticle-mediated drug delivery preferentially targeted to the periablational rim to study whether polymeric micelle-like nanoparticles (MNPs) loaded with anti-IL6 siRNA can be used to suppress thermal ablation-induced IL-6 production, IL-6-mediated periablational cell infiltration, hepatocyte proliferation in untreated liver, and IL-6-mediated downstream RF ablation-induced stimulation of distant tumor growth.