Because the PI3K/mTOR/p70S6K axis is well known to play an important role in cell growth and survival, and is described to be involved in breast cancer cell proliferation and chemoresistance18, we looked at the activation of the p70S6K (p70S6K), which regulates cell cycle, inhibits the pro-apoptotic protein BAD and controls protein synthesis through the phosphorylation of the S6 protein of the 40S ribosomal subunit19. Here, PROS1 is linked to breast cancer.