Conversely, despite CTCF binding between the alternative replication initiation site (rep*) and Cp in the EBV genome of type III Burkitt's lymphoma (BL) cell lines, a high level of CpG methylation has been detected in this region, suggesting CTCF may not be able to prevent methylation across all target sequences [36]. This evidence concerns the gene CTCF and Burkitt lymphoma.