For example, adipose KLB is required for acute insulin sensitizing effects of FGF218, adipose FGFR1 KO9 and lipodystrophic animals36 are completely refractory to the effects of pharmacological FGF21 administration such as weight loss and glucose tolerance, however, in the lipodystrophic animals, liver remained sensitive to the effects of FGF2136. This evidence concerns the gene FGF21 and glucose measurement.