This finding is in agreement with those of Vimal et al who showed that obesity-induced metabolic changes directly affect the transcriptional regulation of Cav-1, the protein expression of Cav-1, and FASN, being the main mediators of proliferation in melanoma cells (Pandey, Vijayakumar, Ajay, Malvi, & Bhat, 2012). Here, CAV1 is linked to obesity due to melanocortin 4 receptor deficiency.