UBQLN2 and amyotrophic lateral sclerosis: To investigate the role of UBLQN2 and ALS-liked mutations in pathology, we used somatic brain transgenesis with rAAV serotype 2/8 to express either EGFP-control, WT or one of three different mutant forms of ubiquilin-2 (P497S, P497H, and P506T) in the developing mouse brain.