UBQLN2 and amyotrophic lateral sclerosis: Mice injected with rAAV2/8-UBQLN2 wild type and ALS-linked mutants all demonstrated widespread neuronal (specific) expression of ubiquilin-2 in the olfactory bulb, cortex, hippocampus, thalamus, striatum, brainstem, and cerebellum as early as 1 month post-injection, and maintained at both 3 and 6 month time points (Fig. 2).