As ubiquilin-2 has been found colocalized with other proteins in ALS inclusions, such as ubiquitin, p62, and FUS [1, 14], we examined brain tissue from mice for co-localization of these and several other neuropathological proteins including pSer129-synuclein, tau, phospho-tau, and TDP-43, which is found both in frontotemporal dementia (FTLD-U) and ALS brains. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.