No significant differences were seen between the 2 groups for gender, age, diabetes duration, history of previous Coronary Heart Disease (CHD), tobacco smoking, BMI, type of ACS, resting heart rate, systolic and diastolic blood pressure, use of antidiabetic agents at time of inclusion in the study (metformin, sulfonylurea or glinide, acarbose, pioglitazone, DPP-4 inhibitor, insulin), use of cardiovascular drugs (ACE inhibitor/ARB, betablocker, antiplatelet agent, statin), baseline values of HbA1c, fructosamine, ventilatory threshold and VO2 peak. The gene discussed is ACE; the disease is diabetes mellitus.