Time course analysis of CD4+CD25+Foxp3+ Treg cells in the spleen of HAT-AT and HA-SC (sham control mice in which liver was damaged but neither Lin− BMCs nor sTreg cells were transplanted) mice showed a significant increase in the percentage of Treg cells in the HAT-AT group in comparison to the HAT-SC group of mice within the first 2 months of transplantation, and the percentages later became comparable (Fig. 3a). The gene discussed is CD4; the disease is ataxia telangiectasia.