Lupus-induced changes in chemokines and cytokines were consistent with both preclinical and clinical findings and indicate specific pathways that might be involved in the development and severity of lupus and NP-SLE symptoms [58], including increased expression of IFNγ [59,60,61,62], IL-10 [62,63,64,65,66,67], IP-10/CXCL10 [68,69,70,71,72,73,74], and MCP-1/CCL2 [71,72,73,74,75,76,77]. This evidence concerns the gene CCL2 and systemic lupus erythematosus.