JAG1 and myeloid sarcoma: Notch receptors are expressed by oligodendroglial cells [47,143] and can be activated by the Delta and Jagged1 ligands expressed by neurons and astrocytes, and they have been found to be up-regulated in experimental models such as EAE and Theiler’s murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) as well as in MS brains [141,144,145,146].