Several altered molecular signaling pathways are involved in CRC onset, such as Wnt/APC/β-catenin, phosphoinositide 3-kinase (PI3K)/AKT/glycogen synthase kinase-3β (GSK-3β), transforming growth factor-β (TGF)-β/Smad, NF- κb or mismatch repair genes (MMR). The gene discussed is GSK3B; the disease is colorectal carcinoma.