CD8A and primary biliary cholangitis: We identified 8 hypomethylated genes and 12 hypermethylated genes in CD4+ cells, 3 hypomethylated genes and 12 hypermethylated genes in CD8+ cells, and 9 hypomethylated genes and 10 hypermethylated genes in CD14+ cells in PBC compared with normal controls (Fig. 2, Table 1).