Importantly, CXCR3 was demonstrated to be significantly hypomethylated in CD4+ T cells from PBC patients (Fig. 3), whereas UBE2A and FUNDC2 were hypermethylated in CD4+ T cells and CD8+ T cells, respectively, in PBC patients (Figs. 4 and 5). This evidence concerns the gene CD4 and primary biliary cholangitis.