TNF-α functions in septic shock by elevating body temperature as an endogenous pyrogen; by inducing vasodilation as well as decreases in blood pressure and tissue perfusion through producing copious NO; by destructing the integrity of vascular barrier both NO-dependently and NO-independently, which increases capillary permeability, enhances plasma extravasation and reduces venous return; by inhibiting the fibrinolytic system, which promotes the hemorrhagic necrosis of vital organs and even disseminated intravascular coagulation during septic shock. Here, TNF is linked to septic shock.