In addition, G allele carriers were significantly more prone to myocardial infarction.12 In patients with acute myocardial infarction and unstable angina, the ones suffering from plaque rupture have higher MMP-9 levels than those without, and the patients have more obvious 1562C-G polymorphism than the controls do. The gene discussed is MMP9; the disease is acute myocardial infarction.