In accordance with major results, patients with type 2 diabetes had declined plasma sfrp5compared with health control population (14.14±11.91ng/mL, 22.98±12.36ng/mL, respectively).15,17 As far as we know, plasma sfrp5 has not been determined in LADA population before. The gene discussed is SFRP5; the disease is type 2 diabetes mellitus.