The cDC vs. pDC signature includes a main regulatory network encompassing PIK3CB, ICAM1, CLEC7A, HLA-DRA, IL1B, and LGALS3 (Figure 9D) and is enriched for “functions of antigen-presenting cells” (p = 10−11.1), “inflammatory response” (p = 10−8.9), “bacterial infection” (p = 10−7.9), “migration of cells” (p = 10−11.4), and “clathrin-mediated endocytosis signaling” pathway (p = 10−4.6) (Figure 11B). The gene discussed is PIK3CB; the disease is bacterial infectious disease.